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Article

Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis.

Nature communications - 9 Feb 2015

Dong Bingning, Lee Ju-Seog, Park Yun-Yong, Yang Feng, Xu Ganyu, Huang Wendong, Finegold Milton J, Moore David D

Abstract excerpt

Aberrant β-catenin activation contributes to a third or more of human hepatocellular carcinoma (HCC), but β-catenin activation alone is not sufficient to induce liver cancer in mice. Differentiated hepatocytes proliferate upon acute activation of either β-catenin or the nuclear xenobiotic receptor CAR. These responses are strictly limited and are tightly linked, since β-catenin is activated in nearly all of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25661872
DOI: 10.1038/ncomms6944
PMCID: PMC4324535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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