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Article

FBP1 controls liver cancer evolution from senescent MASH hepatocytes.

Nature - 1 Jan 2025

Gu Li, Zhu Yahui, Nandi Shuvro P, Lee Maiya, Watari Kosuke, Bareng Breanna, Ohira Masafumi, Liu Yuxiao, Sakane Sadatsugu, Carlessi Rodrigo, Sauceda Consuelo, Dhar Debanjan, Ganguly Souradipta, Hosseini Mojgan, Teneche Marcos G, Adams Peter D, Gonzalez David J, Kisseleva Tatiana, Tirnitz-Parker Janina E E, Simon M Celeste, Alexandrov Ludmil B, Karin Michael

Abstract excerpt

Hepatocellular carcinoma (HCC) originates from differentiated hepatocytes undergoing compensatory proliferation in livers damaged by viruses or metabolic-dysfunction-associated steatohepatitis (MASH)1. While increasing HCC risk2, MASH triggers p53-dependent hepatocyte senescence3, which we found to parallel hypernutrition-induced DNA breaks. How this tumour-suppressive response is bypassed to license oncogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39743585
DOI: 10.1038/s41586-024-08317-9
PMCID: PMC12168545

Genes

FBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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