Article
Testing for Genetic Interactions in Complex Disease With Distance Correlation.
Biometrical journal. Biometrische Zeitschrift - 1 Oct 2026
Castro-Prado Fernando, Costas Javier, Edelmann Dominic, González-Manteiga Wenceslao, Penas David R
Abstract excerpt
Understanding epistasis (genetic interaction) may shed some light on the genomic basis of common diseases, including disorders of maximum interest due to their high socioeconomic burden, like schizophrenia. Distance correlation is an association measure that characterizes general statistical independence between random variables, not only the linear one. Here, we propose distance correlation as a novel tool for...
Read the complete abstract on PubMedTopics
- Epistasis, Genetic
- Humans
- Schizophrenia
- Polymorphism, Single Nucleotide
- Biometry