Article

Negative short-range genomic autocorrelation of causal effects on human complex traits

2020-09-24

Abstract excerpt

Most models of complex trait genetic architecture assume that signed causal effect sizes of each SNP (defined with respect to the minor allele) are uncorrelated with those of nearby SNPs, but it is currently unknown whether this is the case. We develop a new method, autocorrelation LD regression (ACLR), for estimating the genome-wide autocorrelation of causal minor allele effect sizes as a function of genomic dist...

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Literature Corpus work: 868ac265-e402-593c-b714-96c2a7f97286
DOI: 10.1101/2020.09.23.310748

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