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Article

A fast and powerful W-test for pairwise epistasis testing.

Nucleic acids research - 8 Jul 2016

Wang Maggie Haitian, Sun Rui, Guo Junfeng, Weng Haoyi, Lee Jack, Hu Inchi, Sham Pak Chung, Zee Benny Chung-Ying

Abstract excerpt

Epistasis plays an essential role in the development of complex diseases. Interaction methods face common challenge of seeking a balance between persistent power, model complexity, computation efficiency, and validity of identified bio-markers. We introduce a novel W-test to identify pairwise epistasis effect, which measures the distributional difference between cases and controls through a combined log odds...

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Share to Algorithms
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Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CNTNAP2 gene

Share to Logistic Models

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Share to Multifactor Dimensionality Reduction

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 27112568
DOI: 10.1093/nar/gkw347
PMCID: PMC4937324

Genes

SLIT3
CENPN
CNTNAP2
NDST4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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