The Role of Germline Transposable Element Insertions in Pediatric Cancer Predisposition.

Abstract excerpt

At least 10 to 15% of children with cancer have a pathogenic germline variant in a cancer predisposition gene. Studies of germline cancer predisposition, however, have focused primarily on single-nucleotide and copy-number variants, leaving other classes such as transposable elements (TE) largely unexplored. Although rare pathogenic TE insertions have been implicated in inherited cancer, their contribution to...

Topics

• Humans
• Genetic Predisposition to Disease
• DNA Transposable Elements
• Child
• Neoplasms
• Germ-Line Mutation