Article
Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing.
Cancer discovery - 1 Dec 2021
Newman Scott, Nakitandwe Joy, Kesserwan Chimene A, Azzato Elizabeth M, Wheeler David A, Rusch Michael, Shurtleff Sheila, Hedges Dale J, Hamilton Kayla V, Foy Scott G, Edmonson Michael N, Thrasher Andrew, Bahrami Armita, Orr Brent A, Klco Jeffery M, Gu Jiali, Harrison Lynn W, Wang Lu, Clay Michael R, Ouma Annastasia, Silkov Antonina, Liu Yanling, Zhang Zhaojie, Liu Yu, Brady Samuel W, Zhou Xin, Chang Ti-Cheng, Pande Manjusha, Davis Eric, Becksfort Jared, Patel Aman, Wilkinson Mark R, Rahbarinia Delaram, Kubal Manish, Maciaszek Jamie L, Pastor Victor, Knight Jay, Gout Alexander M, Wang Jian, Gu Zhaohui, Mullighan Charles G, McGee Rose B, Quinn Emily A, Nuccio Regina, Mostafavi Roya, Gerhardt Elsie L, Taylor Leslie M, Valdez Jessica M, Hines-Dowell Stacy J, Pappo Alberto S, Robinson Giles, Johnson Liza-Marie, Pui Ching-Hon, Ellison David W, Downing James R, Zhang Jinghui, Nichols Kim E
Abstract excerpt
Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-risk disease. Here, we used a three-platform sequencing approach, including whole-genome sequencing (WGS), whole-exome sequencing (WES), and RNA sequencing (RNA-seq), to examine tumor and germline genomes from 309 prospectively identified children with newly diagnosed (85%) or relapsed/refractory (15%) cancers, unselected...
Read the complete abstract on PubMed