Article
Identification of pathogenic retrotransposon insertions in cancer predisposition genes.
Cancer genetics - 1 Oct 2017
Qian Yaping, Mancini-DiNardo Debora, Judkins Thaddeus, Cox Hannah C, Brown Krystal, Elias Maria, Singh Nanda, Daniels Courtney, Holladay Jayson, Coffee Bradford, Bowles Karla R, Roa Benjamin B
Abstract excerpt
Cancer risks have been previously reported for some retrotransposon element (RE) insertions; however, detection of these insertions is technically challenging and very few oncogenic RE insertions have been reported. Here we evaluate RE insertions identified during hereditary cancer genetic testing using a comprehensive testing strategy. Individuals who had single-syndrome or pan-cancer hereditary cancer genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.