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Expression of EGFR-mutant proteins and genomic evolution in EGFR-mutant transformed small cell lung cancer

1 Sept 2023

Abstract excerpt

Background: The transformation of epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) into small cell lung cancer (SCLC) accounts for 3–14% of the resistance mechanism to EGFR tyrosine kinase inhibitors (TKIs). At present, there is no relevant research to explore the dynamic expression of EGFR-mutant proteins and genomic evolution in EGFR-mutant transformed SCLC/neuroendocrine carcinoma...

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PMID: 37868836
DOI: 10.21037/jtd-23-161

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