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Article

Histological transformation in lung cancer: Mechanisms, clinical characteristics, and therapeutic approaches.

Biochimica et biophysica acta. Reviews on cancer - 1 Oct 2025

Liu Shiyi, Xu Tao, Cao Xiaojing, Li Hecheng, Jin Runsen

Abstract excerpt

Lung cancer, the leading cause of cancer-related mortality globally, exhibits remarkable histological plasticity, with non-small cell lung cancer (NSCLC) frequently transforming into small cell lung cancer (SCLC) as a resistance mechanism to targeted therapies and immunotherapies. The molecular mechanisms and treatments for SCLC transformation remain unclear. This review analyzes the mechanisms, molecular...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

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Source

Identifiers

PMID: 40784437
DOI: 10.1016/j.bbcan.2025.189413

Genes

AURKA
DLL3
EGFR
RB1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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