Small cell lung cancer transformations from non-small cell lung cancer: Biological mechanism and clinical relevance

doi:10.1016/j.pccm.2023.10.005

Article

Small cell lung cancer transformations from non-small cell lung cancer: Biological mechanism and clinical relevance

6 Feb 2024

Abstract excerpt

Lung cancer is a leading cause of cancer deaths worldwide, consisting of two major histological subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). In some cases, NSCLC patients may undergo a histological transformation to SCLC during clinical treatments, which is associated with resistance to targeted therapy, immunotherapy, or chemotherapy. The review provides a comprehensive...

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