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Article

Transcriptomic Heterogeneity of EGFR-Mutant Non-Small Cell Lung Cancer Evolution Toward Small-Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2024

Oh Songji, Koh Jaemoon, Kim Tae Min, Kim Soyeon, Youk Jeonghwan, Kim Miso, Keam Bhumsuk, Jeon Yoon Kyung, Ku Ja-Lok, Kim Dong-Wan, Chung Doo Hyun, Heo Dae Seog

Abstract excerpt

PURPOSE: Histologic transformation from EGFR-mutant non-small cell lung cancer (NSCLC) to small-cell lung cancer (SCLC) is a key mechanism of resistance to EGFR tyrosine kinase inhibitors (TKI). However, transcriptomic changes between NSCLC and transformed SCLC (t-SCLC) remain unexplored. EXPERIMENTAL DESIGN: We conducted whole-transcriptome analysis of 59 regions of interest through the spatial profiling of...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39150541
DOI: 10.1158/1078-0432.CCR-24-0160

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