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Article

Mechanism exploration and model construction for small cell transformation in EGFR-mutant lung adenocarcinomas.

Signal transduction and targeted therapy - 2 Oct 2024

Li Yan, Xie Tongji, Wang Shouzheng, Yang Lin, Hao Xuezhi, Wang Yan, Hu Xingsheng, Wang Lin, Li Junling, Ying Jianming, Xing Puyuan

Abstract excerpt

Small-cell lung cancer (SCLC) transformation accounts for 3-14% of resistance in EGFR-TKI relapsed lung adenocarcinomas (LUADs), with unknown molecular mechanisms and optimal treatment strategies. We performed transcriptomic analyses (including bulk and spatial transcriptomics) and multiplex immunofluorescence on pre-treated samples from LUADs without transformation after EGFR-TKI treatment (LUAD-NT), primary...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39353908
DOI: 10.1038/s41392-024-01981-3
PMCID: PMC11445518

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