Article
Genomic Profiling, Risk Stratification, and Post-Transformation Treatment Outcomes in Patients with Transformed Small-Cell Lung Cancer: A Multicenter Analysis.
Lung cancer (Amsterdam, Netherlands) - 1 Oct 2026
Gao Ruolin, Li ZhenXiang, Huang Jie, Zhao Jun, Wang Yan, Guo Qinxiang, Deng Guangchuan, Bai Hua, Yang Xu, Duan Jianchun, Wang Zhijie, Wang Yuyan, Wang Jingjing, Xu Jiachen, Wan Rui, Sun Boyang, Fei Kailun, Ma Zixiao, Zhong Jia, Wang Jie
Abstract excerpt
BACKGROUND: Transformed small-cell lung cancer (T-SCLC) is an increasingly recognized resistance mechanism in EGFR-mutant lung adenocarcinoma. This study aimed to identify early predictors of histologic transformation and evaluate post-transformation treatment outcomes. METHODS: We retrospectively collected 163 T-SCLC patients from five Chinese centers. Next-generation sequencing was performed on 60 EGFR-mutant...
Read the complete abstract on PubMedTopics
- Humans
- Lung Neoplasms
- Small Cell Lung Carcinoma
- Female
- Mutation