Complex landscape of somatic copy number alterations in head and neck paragangliomas.

doi:10.3389/fendo.2026.1841009

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Complex landscape of somatic copy number alterations in head and neck paragangliomas.

Frontiers in endocrinology - 1 Jan 2026

Pavlov Vladislav S, Fedorova Maria S, Elnukaev Turpal-Ali S M, Kalinin Dmitry V, Pudova Elena A, Katunina Irina V, Guvatova Zulfiya G, Kobelyatskaya Anastasia A, Kaprin Andrey D, Kudryavtseva Anna V, Snezhkina Anastasiya V

Abstract excerpt

Background: Copy number alterations (CNAs) drive cancer by amplifying oncogenes and deleting tumor suppressor genes. Although CNA patterns are well-studied in common cancers, they remain poorly characterized in rare tumors. Methods: In this study, we employed an allele-specific copy number analysis using ASCAT on 25 head and neck paragangliomas (HNPGLs) with high tumor cell purity (≥70%) and available...

Read the complete abstract on PubMed