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Article

Spatiotemporal Heterogeneity Characterizes the Genetic Landscape of Pheochromocytoma and Defines Early Events in Tumorigenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2015

Crona Joakim, Backman Samuel, Maharjan Rajani, Mayrhofer Markus, Stålberg Peter, Isaksson Anders, Hellman Per, Björklund Peyman

Abstract excerpt

PURPOSE: Pheochromocytoma and paraganglioma (PPGL) patients display heterogeneity in the clinical presentation and underlying genetic cause. The degree of inter- and intratumor genetic heterogeneity has not yet been defined. EXPERIMENTAL DESIGN: In PPGLs from 94 patients, we analyzed LOH, copy-number variations, and mutation status of SDHA, SDHB, SDHC, SDHD, SDHAF2, VHL, EPAS1, NF1, RET, TMEM127, MAX, and HRAS...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25991818
DOI: 10.1158/1078-0432.CCR-14-2854

Genes

VHL
EPAS1
HRAS
MAX
RET
SDHA
SDHAF2
SDHB
SDHC
SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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