Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas.

doi:10.1038/ncomms7044

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Article

Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas.

Nature communications - 27 Jan 2015

Castro-Vega Luis Jaime, Letouzé Eric, Burnichon Nelly, Buffet Alexandre, Disderot Pierre-Hélie, Khalifa Emmanuel, Loriot Céline, Elarouci Nabila, Morin Aurélie, Menara Mélanie, Lepoutre-Lussey Charlotte, Badoual Cécile, Sibony Mathilde, Dousset Bertrand, Libé Rossella, Zinzindohoue Franck, Plouin Pierre François, Bertherat Jérôme, Amar Laurence, de Reyniès Aurélien, Favier Judith, Gimenez-Roqueplo Anne-Paule

Abstract excerpt

Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived tumours with a very strong genetic component. Here we report the first integrated genomic examination of a large collection of PCC/PGL. SNP array analysis reveals distinct copy-number patterns associated with genetic background. Whole-exome sequencing shows a low mutation rate of 0.3 mutations per megabase, with few recurrent somatic...

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PMID: 25625332
DOI: 10.1038/ncomms7044
PMCID: PMC4354166

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DLK1
SDHB

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