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Article

Identifying Potential Drug Targets in Coronary Atherosclerosis: Insights from the Druggable Genome and Mendelian Randomization.

Cardiovascular drugs and therapy - 1 Feb 2026

Liu Ruikang, Sun Chiyun, Li Jun, Yang Guangyi, Xu Ke, Hu Jiaming, Meng Chao, Xia Xiao, Li Yonghao, Liu Yiying

Abstract excerpt

PURPOSE: This study aims to identify therapeutic targets for coronary atherosclerosis (CA) using publicly available datasets while exploring its pathophysiologic mechanisms, mediators and potential side effects. METHODS: We conducted a two-sample Mendelian randomization (MR) and single-cell MR analyses integrating identified druggable genes to evaluate the causal relationship between expression quantitative trait...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40214710
DOI: 10.1007/s10557-025-07694-1

Genes

GGCX
NPEPPS
MFGE8
PDGFD
VAMP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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