Article
Weak SLP-76/PLC-γ1 interaction fine-tunes T cell receptor signal strength to optimize T cell responsiveness.
Nature communications - 29 Jul 2026
Yamane Hidehiro, Wada Junya, Stassenko Elizabeth N, Convertino Natalie D, Lee Mariah E, Vacchio Melanie S, Li Wenmei, Livak Ferenc, Rathnayake Udumbara M, Balagopalan Lakshmi, Chari Raj, Hagenau Herbert, Awasthi Parirokh, McGavern Dorian B, Bosselut Remy, Samelson Lawrence E
Abstract excerpt
Upon T cell receptor (TCR) engagement, phosphorylation of the LAT adapter protein enables binding of the enzyme PLC-γ1 to a Gads/SLP-76 dimer, forming a tetrameric structure. The interaction between SLP-76 and PLC-γ1 is weak within this heterotetramer, and the relevant binding sites of SLP-76 and PLC-γ1 are highly conserved in vertebrates. We generated a mouse with a T cell-specific mutation in the SLP-76 that...
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