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Article

Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production.

Blood - 18 Mar 2010

Sonnenberg Gregory F, Mangan Paul R, Bezman Natalie A, Sekiguchi Debora R, Luning Prak Eline T, Erikson Jan, Maltzman Jonathan S, Jordan Martha S, Koretzky Gary A

Abstract excerpt

Central and peripheral tolerance is required to prevent immune responses to self-antigens. We now present a mouse model in which wild-type (WT) SH2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) has been constitutively targeted to the membrane, where CD4+ T cells become spontaneous...

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Identifiers

PMID: 20029045
DOI: 10.1182/blood-2009-08-237438
PMCID: PMC2920203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20029045-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production.PMID 20029045Read ↗

Conditional deletion of SLP‐76 in mature T cells abrogates peripheral immune responsesSemantic proximity Read ↗

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Semantic proximity Read ↗

T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.Semantic proximity Read ↗

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.Semantic proximity Read ↗

Differential role of SLP-76 domains in T cell development and function.Semantic proximity Read ↗

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.Semantic proximity Read ↗

SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling.Semantic proximity Read ↗

Functional hierarchy of the N-terminal tyrosines of SLP-76.Semantic proximity Read ↗

Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis.Semantic proximity Read ↗

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.Semantic proximity Read ↗

T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Semantic proximity Read ↗

Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.Semantic proximity Read ↗

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