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Article

Differential role of SLP-76 domains in T cell development and function.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Kumar Lalit, Pivniouk Vadim, de la Fuente Miguel A, Laouini Dhafer, Geha Raif S

Abstract excerpt

The adapter SLP-76 is essential for thymocyte development. SLP-76(-/-) mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mice reconstituted with Gads-binding site and SH2 domain deletion mutants had decreased thymic cellularity, impaired...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phospholipase C gamma

Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 11792851
DOI: 10.1073/pnas.022619199
PMCID: PMC117400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential role of SLP-76 domains in T cell development and function.PMID 11792851Read ↗

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