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Article

Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.

Cellular signalling - 1 Jan 2015

Lugassy Jennie, Corso Jasmin, Beach Dvora, Petrik Thomas, Oellerich Thomas, Urlaub Henning, Yablonski Deborah

Abstract excerpt

T cell antigen receptor (TCR) signaling depends on three interacting adaptor proteins: SLP-76, Gads, and LAT. Their mechanisms of signaling have been extensively explored, with the aid of fortuitously isolated LAT- and SLP-76-deficient T cell lines, but no such tools were available for Gads, a Grb2-family adaptor that bridges the TCR-inducible interaction between SLP-76 and LAT. TALEN-directed genome editing was...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25452106
DOI: 10.1016/j.cellsig.2014.10.005

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.PMID 25452106Read ↗

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.Semantic proximity Read ↗

Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT.Semantic proximity Read ↗

Weak SLP-76/PLC-γ1 interaction fine-tunes T cell receptor signal strength to optimize T cell responsiveness.Semantic proximity Read ↗

T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Semantic proximity Read ↗

Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.Semantic proximity Read ↗

LAT encodes T cell activation pathway balanceSemantic proximity Read ↗

The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.Semantic proximity Read ↗

Differential role of SLP-76 domains in T cell development and function.Semantic proximity Read ↗

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.Semantic proximity Read ↗

Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells.Semantic proximity Read ↗

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