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Article

Molecular mechanisms underlying the evolution of the slp76 signalosome.

Scientific reports - 4 May 2017

Qu Xuemei, Lan Xin, Deng Chong, Zhou Jiatao, Du Jingjing, Huang Shengfeng, Li Yingqiu

Abstract excerpt

The well-defined mammalian slp76-signalosome is crucial for T-cell immune response, yet whether slp76-signalosome exists in invertebrates and how it evolved remain unknown. Here we investigated slp76-signalosome from an evolutionary perspective in amphioxus Branchiostoma belcheri (bb). We proved slp76-signalosome components bbslp76, bbGADS and bbItk are present in amphioxus and bbslp76 interacts with bbGADS and...

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Identifiers

PMID: 28473706
DOI: 10.1038/s41598-017-01660-0
PMCID: PMC5431462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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