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Article

The adapter proteins LAT and SLP-76 are required for T-cell activation.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 1999

Finco T S, Yablonski D, Lin J, Weiss A

Abstract excerpt

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Topics

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Share to Carrier Proteins
Share to Glycolipids
Share to Adaptor Proteins, Signal Transducing
Share to Jurkat Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Phosphoproteins

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Source

Identifiers

PMID: 11232295
DOI: 10.1101/sqb.1999.64.265

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The adapter proteins LAT and SLP-76 are required for T-cell activation.PMID 11232295Read ↗

The role of SLP-76 and LAT in lymphocyte development.Semantic proximity Read ↗

Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.Semantic proximity Read ↗

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Semantic proximity Read ↗

Regulation of Cellular and Humoral Immune Responses by the SLAM and SAP Families of MoleculesSemantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.Semantic proximity Read ↗

Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.Semantic proximity Read ↗

SLAM family receptors and SAP adaptors in immunity.Semantic proximity Read ↗

Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways.Semantic proximity Read ↗

SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.Semantic proximity Read ↗

LAT polices T cell activation.Semantic proximity Read ↗

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