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Article

Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation.

Frontiers in immunology - 1 Jan 2022

Arbulo-Echevarria Mikel M, Vico-Barranco Inmaculada, Zhang Fanghui, Fernandez-Aguilar Luis M, Chotomska Martyna, Narbona-Sánchez Isaac, Zhang Lichen, Malissen Bernard, Liang Yinming, Aguado Enrique

Abstract excerpt

The LAT transmembrane adaptor is essential to transduce intracellular signals triggered by the TCR. Phosphorylation of its four C-terminal tyrosine residues (136, 175, 195, and 235 in mouse LAT) recruits several proteins resulting in the assembly of the LAT signalosome. Among those tyrosine residues, the one found at position 136 of mouse LAT plays a critical role for T cell development and activation. The...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36569841
DOI: 10.3389/fimmu.2022.1054920
PMCID: PMC9768323

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