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Article

The role of SLP-76 and LAT in lymphocyte development.

Current opinion in immunology - 1 Apr 2000

Pivniouk V I, Geha R S

Abstract excerpt

SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is...

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Source

Identifiers

PMID: 10712938
DOI: 10.1016/s0952-7915(99)00068-0

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of SLP-76 and LAT in lymphocyte development.PMID 10712938Read ↗

The adapter proteins LAT and SLP-76 are required for T-cell activation.Semantic proximity Read ↗

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.Semantic proximity Read ↗

Differential role of SLP-76 domains in T cell development and function.Semantic proximity Read ↗

Conditional deletion of SLP‐76 in mature T cells abrogates peripheral immune responsesSemantic proximity Read ↗

Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.Semantic proximity Read ↗

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.Semantic proximity Read ↗

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.Semantic proximity Read ↗

Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Semantic proximity Read ↗

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.Semantic proximity Read ↗

Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection.Semantic proximity Read ↗

Functional hierarchy of the N-terminal tyrosines of SLP-76.Semantic proximity Read ↗

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