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Article

A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.

Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005

Kumar Lalit, Feske Stefan, Rao Anjana, Geha Raif S

Abstract excerpt

The adapter SLP-76 is essential for T cell development and function. SLP-76 binds to the src homology 3 domain of Lck in vitro. This interaction depends on amino acids 185-194 of SLP-76. To examine the role of the Lck-binding region of SLP-76 in T cell development and function, SLP-76(-/-) mice were reconstituted with an SLP-76 mutant that lacks amino acids 185-194. Double and single positive thymocytes from...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Indirect

Share to Jurkat Cells

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

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Source

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Identifiers

PMID: 16354835
DOI: 10.1073/pnas.0509176102
PMCID: PMC1323183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.PMID 16354835Read ↗

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