Article

Massively parallel jumping assay decodes <i>Alu</i> retrotransposition activity

2024-04-19

Abstract excerpt

The human genome contains millions of retrotransposons, several of which could become active due to somatic mutations having phenotypic consequences, including disease. However, it is not thoroughly understood how nucleotide changes in retrotransposons affect their jumping activity. Here, we developed a novel massively parallel jumping assay (MPJA) that can test the jumping potential of thousands of transposons e...

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Literature Corpus work: de5b136f-f809-5c01-b580-ebea44bcf73a
DOI: 10.1101/2024.04.16.589814

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