Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification.

PLoS genetics - 1 Feb 2026

Unlu Irem, Smiley Marina K, Potapov Vladimir, Renoux-Martin Yoan, Sun Zhi-Yi, Lim Hoong Chuin

Abstract excerpt

Diversity-Generating Retroelements (DGRs) are specialized genetic systems typically harnessed in nature to evolve new molecular recognition. This mechanism, known as mutagenic retrohoming, relies on an error-prone reverse transcriptase (bRT) that introduces errors at template adenines, followed by the incorporation of the resulting mutagenized complementary DNA (cDNA) into a homologous target gene. Although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Genetic Variation

Share to Mutagenesis

Share to Retroelements

Share to RNA-Directed DNA Polymerase

Source

Open in PubMed Open full text

Identifiers

PMID: 41642819
DOI: 10.1371/journal.pgen.1012038
PMCID: PMC12875486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-throughput analyses of a reconstituted diversity-generating retroelement identify intrinsic and extrinsic determinants of diversification.PMID 41642819Read ↗

Accelerated Evolution by Diversity-Generating Retroelements.Semantic proximity Read ↗

Target site recognition by a diversity-generating retroelement.Semantic proximity Read ↗

Diversity-generating Retroelements in Phage and Bacterial Genomes.Semantic proximity Read ↗

Determinants of Adenine-mutagenesis in Diversity-Generating RetroelementsSemantic proximity Read ↗

Template-assisted synthesis of adenine-mutagenized cDNA by a retroelement protein complex.Semantic proximity Read ↗

DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA.Semantic proximity Read ↗

Diversity-generating retroelement homing regenerates target sequences for repeated rounds of codon rewriting and protein diversification.Semantic proximity Read ↗

Core Concepts: How diversity-generating retroelements promote mutation and adaptation in myriad microbes.Semantic proximity Read ↗

Ecology and molecular targets of hypermutation in the global microbiome.Semantic proximity Read ↗

The contribution of DNA repair pathways to genome editing and evolution in filamentous pathogens.Semantic proximity Read ↗

Diversity-generating retroelements: natural variation, classification and evolution inferred from a large-scale genomic survey.Semantic proximity Read ↗

Analysis of a comprehensive dataset of diversity generating retroelements generated by the program DiGReF.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.