Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.

doi:10.3390/ijms27167383

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Article

Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa.

International journal of molecular sciences - 18 Aug 2026

Obadic Bianca G, Katsukunya Jonathan N, Davidson Bianca, Jones Erika S W, Hodkinson Bridget, Freercks Robert, Dandara Collet, Mnika Khuthala

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic component, and lupus nephritis (LN) represents one of its most common and severe organ-specific manifestations. This review synthesises current evidence on the genetic architecture of SLE and LN, with a particular focus on identifying shared and distinct genetic susceptibility loci and highlighting knowledge and data gaps in...

Read the complete abstract on PubMed