Article
Recent insights into the genetic basis of systemic lupus erythematosus.
Genes and immunity - 1 Jul 2009
Moser K L, Kelly J A, Lessard C J, Harley J B
Abstract excerpt
Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four decades later, and with the help of increasingly powerful genetic approaches, more than 25 genes are now known to contribute to the mechanisms that predispose individuals to lupus. Over half of these loci have been discovered in the past...
Topics
- Genetic Predisposition to Disease
- Genome, Human
- Genome-Wide Association Study
- Humans
- Lupus Erythematosus, Systemic