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The genetics of lupus: a functional perspective.

Arthritis research & therapy - 29 May 2012

Guerra Sandra G, Vyse Timothy J, Cunninghame Graham Deborah S

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and is characterized by chronic inflammation and the production of anti-nuclear auto-antibodies. In the era of genome-wide association studies (GWASs), elucidating the genetic factors present in SLE has been a very successful endeavor; 28 confirmed disease susceptibility loci have been mapped. In this review, we summarize...

Topics

Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lupus Erythematosus, Systemic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22640752
DOI: 10.1186/ar3844
PMCID: PMC3446495

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