Shared Genetic Architecture Between Epigenetic Aging and Musculoskeletal Diseases.

doi:10.3390/genes17080878

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Article

Shared Genetic Architecture Between Epigenetic Aging and Musculoskeletal Diseases.

Genes - 28 Jul 2026

Xu Wei, Zhang Xuanyu, Zhao Biyi, Li Xiaoyun, Zhang Ronghua

Abstract excerpt

BACKGROUND: The directional relationship between epigenetic age acceleration (EAA) and musculoskeletal disease remains unresolved. This study integrated bidirectional Mendelian randomization (MR) with multi-layer genomic evidence to evaluate directionality, shared genetic architecture, and robustness to instrument definition. METHODS: Four EAA clocks (IEAA, PhenoAA, HannumAA, and GrimAA) and ten musculoskeletal...

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Share to Aging
Share to Epigenesis, Genetic
Share to Genome-Wide Association Study
Share to Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Musculoskeletal Diseases

Share to Phenotype

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 42650071
DOI: 10.3390/genes17080878
PMCID: PMC13512585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.