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Elucidating the Genetic Underpinnings of Human Musculoskeletal System Aging Through Genomic Structural Equation Modeling.

Clinical genetics - 1 Nov 2025

Xiong Hao, Shen Pan, Luo Qinghua, Zhang Leichang, Li Bo, Ding Zhaohui, Wang Lihua

Abstract excerpt

The genetic architecture underlying traits related to Human Musculoskeletal System Aging (MSA) remains largely unexplored. In this study, we conducted a large-scale multivariate genome-wide association study (GWAS) of MSA utilizing Genomic Structural Equation Modeling (Genomic SEM). We estimated causal single nucleotide polymorphisms (SNPs) associated with independent variation and identified 14 genome-wide...

Topics

Humans
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Aging
Musculoskeletal System
Genetic Predisposition to Disease
Genomics
Male
Phenotype
Female
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

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PMID: 40369705
DOI: 10.1111/cge.14766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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