Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elucidating the Genetic Underpinnings of Human Musculoskeletal System Aging Through Genomic Structural Equation Modeling.

Clinical genetics - 1 Nov 2025

Xiong Hao, Shen Pan, Luo Qinghua, Zhang Leichang, Li Bo, Ding Zhaohui, Wang Lihua

Abstract excerpt

The genetic architecture underlying traits related to Human Musculoskeletal System Aging (MSA) remains largely unexplored. In this study, we conducted a large-scale multivariate genome-wide association study (GWAS) of MSA utilizing Genomic Structural Equation Modeling (Genomic SEM). We estimated causal single nucleotide polymorphisms (SNPs) associated with independent variation and identified 14 genome-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aging
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomics

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Transcriptome

Source

Identifiers

PMID: 40369705
DOI: 10.1111/cge.14766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elucidating the Genetic Underpinnings of Human Musculoskeletal System Aging Through Genomic Structural Equation Modeling.PMID 40369705Read ↗

Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk.Semantic proximity Read ↗

Exploring the shared genetic architecture of sarcopenia using genomic structural equation modeling.Semantic proximity Read ↗

Genomic structural equation modeling reveals the shared genetic architecture of osteosarcopenia across five musculoskeletal phenotypes.Semantic proximity Read ↗

Unraveling 'F' factor: towards a genetic-clinical framework for the musculoskeletal-heart crosstalk in metabolic aging.Semantic proximity Read ↗

Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders.Semantic proximity Read ↗

Shared Genetic Architecture Between Epigenetic Aging and Musculoskeletal Diseases.Semantic proximity Read ↗

Multi-omics and molecular testing: A new insight into the genetic mechanisms of sarcopenia and arthritis.Semantic proximity Read ↗

Using deep learning to analyze the compositeness of musculoskeletal aging reveals that spine, hip and knee age at different rates, and are associated with different genetic and non-genetic factorsSemantic proximity Read ↗

Genetic epidemiology in aging research.Semantic proximity Read ↗

MskAge - An Epigenetic Biomarker of Musculoskeletal Age Derived from a Genetic Algorithm Islands ModelSemantic proximity Read ↗

Novel genomic loci influence patterns of structural covariance in the human brainSemantic proximity Read ↗

Multi-omics and molecular testing: A new insight into the genetic mechanisms of sarcopenia and arthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.