Article

Genetically Proxied Telomere Length but Not Epigenetic Aging Acceleration Causally Influences Healthspan: A Mendelian Randomization Study

2025-07-15

Abstract excerpt

<h4>Objective</h4> To assess the causal effects of leukocyte telomere length (TL) and epigenetic age acceleration (EAA) on healthspan. <h4>Methods</h4> We performed two-sample Mendelian randomization (MR) analyses in accordance with STROBE-MR guidelines. Genetic instrumental variables (IVs) for TL and four EAA biomarkers (Hannum, GrimAge, PhenoAge, and intrinsic EAA) were derived from published genome-wide assoc...

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Literature Corpus work: eba4ed2b-2ba5-53e0-b9e6-09588f170474
DOI: 10.1101/2025.07.14.25331527

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