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Article

Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk.

Journal of translational medicine - 3 Nov 2025

Zhou Yunqiao, Huang Jian, Xu Leqin, Zhang Fan, Bai Chunxiao, Fan Fangyang, Wang Yuquan, Fang Bixuan, Wang Tian, Mu Xiaohong, Li Jinyu

Abstract excerpt

OBJECTIVE: Skeletal aging, a core determinant of systemic aging, poses a global public health challenge due to its association with chronic diseases and functional decline. This study aimed to decode the genetic architecture of skeletal aging by identifying novel loci and multi-system crosstalk using genomic structural equation modeling (Genomic SEM). METHODS: We integrated genome-wide association study (GWAS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41185046
DOI: 10.1186/s12967-025-07104-y
PMCID: PMC12581572

Genes

LBP
LSS
CFI
DPP8
GRAMD4
MTPAP
RUNX2
SLC33A1
SP7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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