Article
Genetic Evidence for Causal Effects of Socioeconomic, Lifestyle, and Cardiometabolic Factors on Epigenetic-Age Acceleration.
The journals of gerontology. Series A, Biological sciences and medical sciences - 8 Jul 2023
Kong Lijie, Ye Chaojie, Wang Yiying, Hou Tianzhichao, Zheng Jie, Zhao Zhiyun, Li Mian, Xu Yu, Lu Jieli, Chen Yuhong, Xu Min, Wang Weiqing, Ning Guang, Bi Yufang, Wang Tiange
Abstract excerpt
GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration (PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging, standing out in predicting mortality and age-related cardiometabolic morbidities. Causal risk factors for GrimAgeAccel and PhenoAgeAccel are unclear. In this study, we performed 2-sample univariable and multivariable Mendelian randomization (MR) to investigate causal...
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