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Article

Cross-Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank.

International journal of rheumatic diseases - 1 Sept 2026

Liu Sisi, Wang Weishu, Li Chengxu, Lai Yuxin, Zhou Zhounan, Han Menglin, Zhang Yujie, Zhang Yan, Tang Ke, Sun Haitao, Yang Qian, Zeng Muhui, Fan Tianxiang, Li Zhong Alan, Ding Changhai, Hunter David J, Zhu Zhaohua

Abstract excerpt

OBJECTIVE: To evaluate the relationship between biological ages and the prevalence and incidence of osteoarthritis (OA). METHODS: 332 261 participants from UK Biobank were analyzed. Biological aging was measured using phenotypic age (PhenoAge) and Klemera-Doubal (KDMAge). KDMAge was derived from nine clinical biomarkers to gauge system integrity decline, while PhenoAge was computed from chronological age and nine...

Read the complete abstract on PubMed

Topics

Humans
Cross-Sectional Studies
Osteoarthritis
Female
Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aging

Risk Factors

Middle Aged

United Kingdom

Incidence

Male

Longitudinal Studies

UK Biobank

Age Factors

Prevalence

Risk Assessment

Phenotype

Biological Specimen Banks

Source

Open in PubMed Open full text

Identifiers

PMID: 42687813
DOI: 10.1111/1756-185x.70853
PMCID: PMC13539371

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