Article

Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease

2023-09-01

Abstract excerpt

Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Using genomic data, this study elucidates biological mechanisms, key risk factors, and causal pathways underlying their comorbidity. We show that CVDs share a large proportion of their genetic risk factors with MDD. Multivariate genome-wide association analysis of the shared genetic lia...

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Literature Corpus work: 8bf18568-88e9-5599-ad48-438ab71ec4fe
DOI: 10.1101/2023.09.01.23294931

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