Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic heterogeneity affects the risk of incident depression, comorbidity, and response to environment: A prospective trajectory study.

Psychological medicine - 22 Jun 2026

Pan Chuyu, Cheng Shiqiang, Qi Xin, Cheng Bolun, Feng Jin, Kang Meijuan, Liu Li, Yang Xuena, Wen Yan, Jia Yumeng, Liu Huan, Zhang Feng

Abstract excerpt

BACKGROUND: Depression exhibits significant heterogeneity in its genetic underpinnings. The role of genetic components in the development of depression and its comorbidities remains insufficiently explored. METHODS: First, depression risk loci from a large-scale genome-wide meta-analysis were annotated to Gene Ontology (GO) terms by functional enrichment. GO-based polygenic risk scores (GO-PRS) were then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comorbidity
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder

Share to Gene-Environment Interaction

Share to Genetic Heterogeneity

Share to Genetic Risk Score

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 42324796
DOI: 10.1017/S0033291726104140
PMCID: PMC13319487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic heterogeneity affects the risk of incident depression, comorbidity, and response to environment: A prospective trajectory study.PMID 42324796Read ↗

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies.Semantic proximity Read ↗

Unique genetic and risk-factor profiles in multimorbidity clusters of depression-related disease trajectories from a study of 1.2 million subjectsSemantic proximity Read ↗

Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.Semantic proximity Read ↗

Identification of 64 new risk loci for major depression, refinement of the genetic architecture and risk prediction of recurrence and comorbiditiesSemantic proximity Read ↗

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.Semantic proximity Read ↗

The Role of Genetic Data in Dissecting Depression Heterogeneity.Semantic proximity Read ↗

Genetic heterogeneity and subtypes of major depressionSemantic proximity Read ↗

Phenome-wide screening of the putative causal determinants of depression using genetic data.Semantic proximity Read ↗

Dissecting Pleiotropy Between Major Depressive Disorder and Physical Disease ComorbiditiesSemantic proximity Read ↗

Phenomic Network Analysis for Depression Reveals Comorbidity Architecture, Genomic Relationships, and Pleiotropic VariantsSemantic proximity Read ↗

Atypical depression shares genetic predisposition with immuno-metabolic traits: a population-based studySemantic proximity Read ↗

Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom ContinuumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.