Article
Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease.
Nature cardiovascular research - 1 Jun 2024
Bergstedt Jacob, Pasman Joëlle A, Ma Ziyan, Harder Arvid, Yao Shuyang, Parker Nadine, Treur Jorien L, Smit Dirk J A, Frei Oleksandr, Shadrin Alexey A, Meijsen Joeri J, Shen Qing, Hägg Sara, Tornvall Per, Buil Alfonso, Werge Thomas, Hjerling-Leffler Jens, Als Thomas D, Børglum Anders D, Lewis Cathryn M, McIntosh Andrew M, Valdimarsdóttir Unnur A, Andreassen Ole A, Sullivan Patrick F, Lu Yi, Fang Fang
Abstract excerpt
Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.