Article
The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential.
BMC biology - 30 May 2022
Kfoury-Beaumont N, Prakasam R, Pondugula S, Lagas J S, Matkovich S, Gontarz P, Yang L, Yano H, Kim A H, Rubin J B, Kroll K L
Abstract excerpt
BACKGROUND: Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal brain development in tumorigenesis. For example, lysine 27 to methionine mutation (H3K27M) in the H3F3A gene occurs...
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