Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas

23 Feb 2023

Abstract excerpt

Diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) are the most lethal brain tumors that primarily occur in pediatric and adult patients, respectively. Both tumors exhibit significant heterogeneity, shaped by distinct genetic/epigenetic drivers, transcriptional programs including RNA splicing, and microenvironmental cues in glioma niches. However, the spatial organization of cellular states and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to RNA Research and Splicing
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36823172
DOI: 10.1038/s41467-023-36707-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomasPMID 36823172Read ↗

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical nichesSemantic proximity Read ↗

Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastomaSemantic proximity Read ↗

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.Semantic proximity Read ↗

Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell ResolutionSemantic proximity Read ↗

Glioblastoma cells increase expression of notch signaling and synaptic genes within infiltrated brain tissueSemantic proximity Read ↗

Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmapSemantic proximity Read ↗

Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic nicheSemantic proximity Read ↗

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.Semantic proximity Read ↗

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade gliomaSemantic proximity Read ↗

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptationsSemantic proximity Read ↗

Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA-sequencing datasetsSemantic proximity Read ↗

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seqSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.