Article
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Cell stem cell - 6 May 2021
Bressan Raul Bardini, Southgate Benjamin, Ferguson Kirsty M, Blin Carla, Grant Vivien, Alfazema Neza, Wills Jimi C, Marques-Torrejon Maria Angeles, Morrison Gillian M, Ashmore James, Robertson Faye, Williams Charles A C, Bradley Leanne, von Kriegsheim Alex, Anderson Richard A, Tomlinson Simon R, Pollard Steven M
Abstract excerpt
Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K27M preferentially within the hindbrain. The reasons for this contrasting etiology are unknown. By engineering human fetal neural stem cell cultures from distinct...
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