Integrative Multi-Omics-Informed Analysis Identifies Insulin Therapy-Associated Loci Implicated in Osteoarthritis Susceptibility.

doi:10.1111/cbdd.70384

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Article

Integrative Multi-Omics-Informed Analysis Identifies Insulin Therapy-Associated Loci Implicated in Osteoarthritis Susceptibility.

Chemical biology & drug design - 1 Aug 2026

Rong Lingbo, Zhu Jiayong, Liu Yifan, Dai Tianyu, Chen Liaobin, Wang Hui

Abstract excerpt

Integrative genetic approaches can combine Mendelian randomization, variant annotation, pathway-level interpretation, and exploratory cellular measurements to investigate complex disease mechanisms. However, the relationship between genetic liability to insulin medication use and osteoarthritis (OA) remains incompletely characterized GWAS summary statistics for insulin medication use were obtained from the UK...

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PMID: 42644749
DOI: 10.1111/cbdd.70384
PMCID: PMC13510103

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