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Article

T1D-Related Cataract Risk Amplification: Mendelian Randomisation Confirms a Dual Hit of Immune-Inflammatory Burden and Metabolic Stress.

Combinatorial chemistry & high throughput screening - 1 Jan 2026

Wang Xue, Guo Kunling, Li Rui, Tang Jiancen, Lou Wei, Wang Mengyu, Du Wei, Cui Hongping, Li Qian

Abstract excerpt

BACKGROUND/OBJECTIVE: Observational studies have linked diabetes with cataracts, but they cannot fully elucidate the underlying causes and mechanisms. This investigation aims to evaluate the causal relationship between genetically predicted diabetes and cataract risk utilizing Mendelian randomisation (MR) techniques. METHODS: We identified single nucleotide polymorphisms (SNPs) with a significant threshold of P <...

Read the complete abstract on PubMed

Topics

Cataract
Humans
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Inflammation

Stress, Physiological

Risk Factors

Source

Identifiers

PMID: 41088899
DOI: 10.2174/0113862073425549250926170012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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