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Article

Mendelian randomization analysis to identify potential drug targets for osteoarthritis

11 Feb 2025

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is a prevalent chronic joint disease for which there is a lack of effective treatments. In this study, we used Mendelian randomization analysis to identify circulating proteins that are causally associated with OA-related traits, providing important insights into potential drug targets for OA. METHOD: Causal associations between 1553 circulating proteins and five OA-related traits...

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PMID: 39932908
DOI: 10.1371/journal.pone.0316824

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