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Article

Association of lipid-lowering drugs with osteoarthritis outcomes from a drug-target Mendelian randomization study.

PloS one - 1 Jan 2024

Ma Weiwei, Chen Honggu, Zhang Zhiwen, Xiong Yong

Abstract excerpt

BACKGROUND: Osteoarthritis (OA), a prevalent musculoskeletal disorder, has been suggested to have a potential association with metabolic syndrome, particularly lipid metabolism. Studies exploring the effects of lipid-lowering drugs on OA have yielded conflicting results. OBJECTIVE: This study employed a drug-targeted Mendelian randomization approach to investigate the association between genetically predicted...

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Topics

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Share to Cholesterol, LDL
Share to HMGCR gene
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypolipidemic Agents

Share to Mendelian Randomization Analysis

Share to Osteoarthritis, Knee

Share to Polymorphism, Single Nucleotide

Share to Proprotein Convertase 9

Source

Open in PubMed Open full text

Identifiers

PMID: 38416763
DOI: 10.1371/journal.pone.0293960
PMCID: PMC10901306

Genes

HMGCR
LDLR
NPC1L1
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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