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Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease.

Diabetes, obesity & metabolism - 1 Feb 2025

Geng Jiawei, Ruan Xixian, Wu Xing, Chen Xuejie, Fu Tian, Gill Dipender, Burgess Stephen, Chen Jie, Ludvigsson Jonas F, Larsson Susanna C, Li Xue, Du Zhongyan, Yuan Shuai

Abstract excerpt

AIMS: The molecular mechanisms underlying the association between type 2 diabetes (T2D) and gastrointestinal (GI) disease are unclear. To identify protein pathways, we conducted a two-stage network Mendelian randomisation (MR) study. MATERIALS AND METHODS: Genetic instruments for T2D were obtained from a large-scale summary-level genome-wide meta-analysis. Genetic associations with blood protein levels were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39592890
DOI: 10.1111/dom.16087
PMCID: PMC7617254

Genes

ADH1B
SULT2A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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