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Article

Diabetes Genetic Clusters and Clinical Outcomes in American Indians.

Diabetes - 1 Nov 2025

Reynolds Kaylia M, Sun Quan, Zhang Ying, Umans Jason, Cole Shelley A, Morris Andrew P, Franceschini Nora

Abstract excerpt

Diabetes has a large medical and public health impact in American Indians. Studies have used genetic data to distinguish type 1 diabetes (T1D) and type 2 diabetes (T2D) and uncover biologic mechanisms underlying T2D clinical heterogeneity. We applied a T1D polygenic score (PS) to 3,084 American Indians (mean age 56 years, 58% women, 39% diabetes). We also calculated partitioned PS for eight clusters of...

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Topics

Adult
Aged
Female
Humans
Male
Middle Aged
American Indian or Alaska Native

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Diabetes Mellitus, Type 1

Diabetes Mellitus, Type 2

Genetic Predisposition to Disease

Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 40824997
DOI: 10.2337/db25-0322
PMCID: PMC12585164

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